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Compare prescription weight-loss medications, including GLP-1 receptor agonists and appetite-control treatments, alongside lower-cost generic options.

About Weight Loss medications

Weight-loss medications work in different ways. GLP-1 receptor agonists such as semaglutide and tirzepatide mimic gut hormones that regulate appetite and slow stomach emptying, while orlistat reduces how much dietary fat your body absorbs. Because the mechanisms differ, so do the side-effect profiles, the injection or tablet schedule, and the monthly cost.

Several products in this category are also licensed for type 2 diabetes under a different brand name — semaglutide is sold as both Ozempic and Wegovy, and tirzepatide as both Mounjaro and Zepbound. The active ingredient is the same, but the approved dose range and indication are not, so you will find them listed under both categories here.

Prices shown include our price-match guarantee. Your prescriber decides which treatment is appropriate for you based on your BMI, medical history and any other medications you take.

Weight Loss — frequently asked questions

What is the difference between Ozempic and Wegovy?
Both contain semaglutide. Ozempic is approved for type 2 diabetes and Wegovy is approved for chronic weight management, and the two use different maximum doses. Your prescriber will specify which one your prescription is for.
Are generic weight-loss medications available?
Generic orlistat is widely available. Generic semaglutide is now stocked as well. Generics contain the same active ingredient as the brand and must meet the same standards for strength, quality and purity.
Do I need a prescription to order?
Yes. Prescription medications require a valid prescription from your licensed prescriber. After you place your order you can upload, email, fax or mail it to us, and our pharmacy team verifies it before anything ships. Over-the-counter items and supplies do not need a prescription.
How long does delivery take?
Standard delivery to the United States usually takes 2 to 4 weeks from the day your prescription is approved. Expedited shipping is available at checkout, and temperature-sensitive medications ship in cold-chain packaging.

Ordering Weight Loss medications from Polar Bear Meds

We currently list 11 weight loss products. Every order is dispensed by a licensed pharmacy and shipped to your door in the United States, with our price-match guarantee on every item. Cannot find your medication? Browse all categories, search by drug name, or contact our team and we will source it for you.

This information is provided for general education and does not replace advice from your doctor or pharmacist. Always follow the directions on your prescription.

Price matching guarantee certificate

We offer competitive pricing on all our medications. We'll match if you find a lower price on an identical product at a verified Canadian online pharmacy!

Eligibility Criteria:

  • The competitor's price must be active (no past/future sales).
  • It is only valid for Canadian online pharmacies with a verifiable address.
  • The product must match the strength, pack size, quantity, manufacturer & origin.
  • There are no price matches on used/expired medications.
  • You must submit your requests before placing an order.
  • We cannot adjust prices after purchase.
  • Request via live chat or phone before placing your order.

Need help? Call our friendly support team at 1-888-779-2193 or fill out the Contact Form