Victoza

Victoza is an FDA-approved once-daily injectable medication with active ingredient Liraglutide prescribed to lower blood sugar levels in individuals aged 10 and above with Type 2 diabetes. Additionally, it’s approved to reduce the risk of heart-related issues in specific adults with Type 2 diabetes. As a GLP-1 agonist, Victoza stimulates insulin release, inhibits sugar release by the body, and slows digestion. Common side effects include nausea, vomiting, diarrhea, and constipation. It’s essential to monitor for these effects while on Victoza and consult a healthcare professional if they persist or worsen.

Victoza is a GLP-1 receptor agonist medication approved by the FDA containing active ingredient Liraglutide. It is prescribed for the management of type 2 diabetes in adults. It mimics the action of the GLP-1 hormone in the body. By stimulating insulin release and slowing down stomach emptying, Victoza helps regulate blood glucose levels in individuals with type 2 diabetes. It is used to improve glycemic control in adults with type 2 diabetes. It is generally prescribed as an adjunct to diet and exercise to help lower blood sugar levels.

Victoza should be administered as a subcutaneous injection once daily, preferably at the same time each day. The recommended starting dose of Victoza is 0.6 mg, administered subcutaneously once daily for the first week. After the first week, the dosage may be increased to 1.2 mg once daily. If further glycemic control is needed, the dosage may be increased to 1.8 mg once daily.

It is essential to follow the prescribed dosing instructions and stay within the recommended dosage. It should be stored refrigerated between 36°F and 46°F (2°C and eight °C) until the first use. Before starting Victoza, patients should inform their healthcare provider about all other medications, including over-the-counter drugs, supplements, and herbal products, to avoid potential drug interactions.

Victoza is used for,

• Type 2 diabetes in people age 10 and older, in addition to diet and exercise.
• Lowering the risk of major heart-related problems (like heart attack) in adults with Type 2 diabetes and heart disease.
• Chronic weight management in those who are obese (BMI ≥ 30 kg/m²) or overweight (BMI ≥ 27 kg/m²) with at least one weight-related condition.

Dosage

Victoza is used once per day. When starting Victoza, your doctor will have you take a starting dose lower than you need to manage your blood sugar levels. After a while, they’ll raise your dose. Your physician can tell you the highest dose of Victoza per day.

Form and Strengths

Victoza comes as a solution in a prefilled pen. It consists of 6 milligrams (mg) of Liraglutide in every milliliter (mL) solution.

What Are the Recommended Victoza Doses for Different Patients?

The dosing for Victoza (Liraglutide) can vary based on the patient’s needs & response to the medication. Here’s a general guideline on the recommended doses:

For Adult Patients

• In the first week of treatment, Victoza should be injected subcutaneously once daily for 0.6 mg. A daily dosage of 0.6 mg is intended to reduce gastrointestinal symptoms and is ineffective for controlling adult blood sugar levels.
• Increase the dosage to 1.2 mg once daily after one week of 0.6 mg subcutaneously injected once daily.

Upon completing at least one week of treatment with the 1.2 mg once daily, increase the dosage to 1.8 mg injected subcutaneously once daily if additional glycemic control is needed.

Pediatric Patients Aged 10 Years and Older

• As a starting dosage, Victoza should be injected subcutaneously once a day at a dose of 0.6 mg.
• The maximum recommended dose is 1.8 mg injected subcutaneously once per day.

After at least one week on the current dosage, increase the dosage by 0.6 mg in increments if additional glycemic control is required.

Dosing Adjustment

• Kidney impairment, mild-to-severe, no dosage adjustment necessary
• In patients with ESRD, there have been reports of acute renal failure and chronic renal failure, which may occasionally need hemodialysis; use caution in patients who experience dehydration.
• Liver impairment, mild-to-severe; no dosage adjustment necessary

Limitations of Use for Victoza

Not for treatment of type 1 diabetes mellitus or diabetic ketoacidosis (not effective for these conditions)

To take Victoza (Liraglutide), follow these general steps:

Wash your hands thoroughly with soap and water. Gather the necessary supplies, including a Victoza pen, a new disposable needle, and an alcohol swab.

Check the Victoza pen visually. Make sure the solution is clear and colorless. Do not use the pen if the solution appears discolored or has particles.

If you use a new pen or last used a while ago, you may need to prime it. Follow the instructions provided with the pen for priming.

Common injection sites include the abdomen, thigh, or upper arm. Clean the chosen site with an alcohol swab and let it dry completely.

Hold the Victoza pen with the needle pointing downward. Insert the needle into the skin at a 90-degree angle (perpendicular to the skin surface) and push the button to deliver the dose. Keep the button pressed until the dose counter returns to 0.

After the injection is complete, remove the needle from the skin. Do not rub the injection site.

Take Victoza 6 mg/ml injection once daily at the same time each day, as prescribed by your healthcare provider.

Avoid injecting Victoza 6 mg/ml injection into a vein or muscle as it is intended for subcutaneous injection.

[Note: It’s important to follow the specific instructions provided by your healthcare provider or pharmacist when taking Victoza].

Victoza works by mimicking the action of a hormone called glucagon-like peptide-1 (GLP-1), which is naturally produced in the body. Victoza binds to GLP-1 receptors in the pancreas when injected, stimulating insulin release in response to elevated blood sugar levels. This helps lower blood sugar levels.

Additionally, Victoza slows down the rate at which the stomach empties, reducing appetite and promoting feelings of fullness, which can aid in weight loss. It also reduces the secretion of glucagon, a hormone that raises blood sugar levels. Overall, Victoza 6 mg/ml injection helps improve blood sugar control and may aid in weight management in people with type 2 diabetes.

Some people may have common side effects during their Victoza treatment. Examples of Victoza’s commonly noted side effects include:

• Nausea: Nausea is one of the most common & frequently reported side effects of Victoza. It involves a sensation of discomfort in the stomach, often led by an urge to vomit. This feeling can occur shortly after the administration of the medication and might persist for a few hours or longer.
• Vomiting: Vomiting, or forcefully expelling the contents of the stomach through the mouth, can occur as a direct response to the body’s inability to tolerate Victoza. This reaction might be immediate or follow the sensation of nausea.
• Decrease in Appetite: Many users experience a reduction in their appetite. This effect can be beneficial for your weight management but might also lead to inadequate nutrition if the decreased appetite is significant and persistent.
• Diarrhea: Diarrhea involves frequent, loose, or watery stools. This side effect can lead to dehydration if fluids are not adequately replaced. It usually occurs as the body’s gastrointestinal system reacts to the presence of the medication.
• Indigestion (Upset Stomach): Indigestion, or dyspepsia, is a common side effect characterized by persistent or recurrent pain or discomfort in the upper abdomen. Symptoms of indigestion include bloating, a feeling of fullness, and gastric discomfort that can occur during or after meals.

You may have mild side effects from using Victoza. Some of the mild side effects that have been reported with Victoza include:

• Low Blood Sugar (Hypoglycemia): Common in patients using diabetes medications, symptoms may include shakiness, anxiety, sweating, hunger, and palpitations.
• Anorexia: This side effect, characterized by a decreased desire to eat, can lead to nutritional deficiencies if persistent.
• Decreased Appetite: Similar to anorexia, a reduced appetite can affect your nutritional intake, though it is generally less severe than anorexia.
• Headache: This can vary from mild to severe and may occur as the body adjusts to the medication.
• Vomiting: An occasional side effect that can lead to dehydration if persistent.
• Burping: Often harmless, it can be frequent or bothersome for some individuals.
• Indigestion: This can include symptoms like stomach discomfort, bloating, and nausea.
• Inflamed Stomach (Gastritis): Symptoms may include stomach ache, nausea, and vomiting.
• Gastroesophageal Reflux Disease (GERD): This includes symptoms such as heartburn, where stomach acid flows back into the esophagus, causing irritation.
• Painful or Swollen Tummy (Abdomen): This discomfort can be a sign of gas, constipation, or other gastrointestinal issues.
• Constipation: A common side effect that involves infrequent or difficult bowel movements.
• Flatulence: An increase in gas production within the gastrointestinal tract can lead to discomfort.
• Infection of the Upper Airways: Symptoms might include coughing, sore throat, and nasal congestion.
• Injection Site Reactions: These can range from bruising, pain, irritation, itching, and rash at the site of injection.
• Increased Heart Rate: Some patients might experience a noticeable increase in heart rate.

These will likely be temporary in most cases. It may also be possible to manage some of them easily. Talk with your doctor or pharmacist if you experience any symptoms that persist or bother you. Victoza should only be stopped if your doctor recommends it.

Adverse/Serious Side Effects

It is possible to experience serious side effects while using Victoza, even though they are rare. Serious side effects that have been reported with Victoza include:

• Risk of Thyroid Tumor: Victoza has been linked to an increased risk of thyroid tumors, including cancerous tumors. This effect has been observed in animal studies, and it is possible it could occur in humans as well. The mechanism involves the stimulation of certain receptors on thyroid cells, which may lead to cell growth and tumor formation.
• Pancreatitis (Swelling of Your Pancreas): Victoza can cause inflammation of the pancreas, known as pancreatitis. This severe condition can be acute or chronic and lead to severe abdominal pain which can radiate to the back, accompanied by nausea, vomiting, and a rapid pulse. Pancreatitis is a serious condition because it can lead to permanent pancreatic damage if not addressed promptly.
• Allergic Reaction: Some individuals may experience severe allergic reactions to Victoza. Symptoms can include itching, rash, difficulty breathing, & swelling of your face, lips, tongue, or throat. These reactions can occur shortly after the drug is administered and require immediate medical attention.
• Kidney Problems: Victoza has been observed to affect kidney proper function in some patients, which can lead to kidney failure in severe cases. Symptoms of kidney problems might include changes in urine color, swelling in the feet or ankles, fatigue, or an unusual tired feeling.
• Gallbladder Problems: Use of Victoza has been associated with gallbladder issues, such as gallstones or inflammation of the gallbladder (cholecystitis). Symptoms or signs can include pain in the upper right abdomen, fever, and jaundice (yellowing of the skin and eyes).
• Severe Low Blood Sugar: Although more common in diabetic medications that directly lower blood sugar, Victoza can also contribute to episodes of severe hypoglycemia, especially when used with other diabetic medications. Symptoms of severe low blood sugar include shaking, sweating, fast heartbeat, dizziness, hunger, headache, and irritability.

[Note: Immediately contact your doctor if you develop serious side effects from Victoza 6 mg/ml injection. Immediately call 911 if the side effects seem life-threatening].

As it falls under the class of drugs known as GLP-1 receptor agonists, you need to consider some warnings when you buy Victoza online. Here are some of the primary warnings associated with Victoza:

Inflammation of the Pancreas (Pancreatitis)

If the pancreas becomes inflamed, it can be fatal. If you have any of the following conditions, tell your healthcare provider before taking Liraglutide:

• Inflamed pancreas
• High blood triglyceride levels
• Stones in your gallbladder (gallstones)
• Alcoholism

You are more likely to get pancreatitis if you have these medical conditions. Liraglutide may increase the risk of pancreatitis if you have these conditions. When you experience extreme abdomen pain that will not go away, stop taking Liraglutide and call your healthcare provider right away. Pain may occur with or without vomiting. From your abdomen to your back, you may feel pain. It may be a symptom of pancreatitis if you experience this type of pain.

Other Important Warnings

Tell your doctor about any health conditions or problems you may have, including:

• Diabetes type 1
• You or any member of your family has had medullary thyroid cancer.
• You have Multiple Endocrine Neoplasia type 2 (MEN2). A person with this disease has tumors in more than one gland in their body.
• Ever had diabetic ketoacidosis (DKA)
• Have a high heart rate.
• Have liver problems
• If you have any heart disease, such as heart rhythm disturbances, angina, or congestive heart failure, or if you have ever had a myocardial infarction (heart attack).
• Have a condition called heart block (bradycardia)
• Have kidney problems
• Have severe diarrhea, vomiting, or dehydration.
• Have gastrointestinal problems
• You are nursing or planning to breastfeed
• You are pregnant or planning to get pregnant
• You are allergic to Liraglutide or any of its ingredients. Allergic reactions can cause the following symptoms:
  • Face, lips, tongue, or throat swelling
  • Feeling dizzy or faint
  • An extremely rapid heartbeat
  • Breathing or swallowing problems
  • Itching or rash that is severe

If you are still determining whether you have any of these conditions, consult your healthcare provider.

What Is the Boxed Warning for Victoza (Thyroid Tumors)?

During drug testing, rats and mice developed thyroid tumors after taking Liraglutide. Some of these tumors were cancerous. In humans, it is unknown whether Liraglutide will cause thyroid tumors or medullary thyroid cancer. If not detected and treated early, medullary thyroid cancer may result in death. A thyroidectomy may be necessary if you develop tumors or cancer of the thyroid.

Liraglutide should not be taken if you or any of your family members have had thyroid cancer, especially medullary thyroid cancer, or Multiple Endocrine Neoplasia syndrome type 2. This group of people already has a higher risk of developing medullary thyroid cancer and should not take Liraglutide.

You should tell your healthcare provider if you experience a lump or swelling in your neck, hoarseness, difficulty swallowing, or shortness of breath while taking Liraglutide. There is a possibility that these are symptoms of thyroid cancer.

When you buy Victoza USA, it’s important to be aware of several precautions to ensure effective use. Here are some key precautions to consider:

Acute Pancreatitis: Patients should be informed of the signs and symptoms of pancreatitis, such as persistent severe abdominal pain, sometimes radiating to the back, and should be instructed to discontinue Victoza and seek medical attention if pancreatitis is suspected.

Renal Impairment: Victoza should be used cautiously in patients with renal impairment, and the dose should be adjusted according to renal function.

Hypoglycemia: Victoza increases the risk of hypoglycemia when combined with a sulfonylurea or insulin. Patients should be educated on recognizing and managing hypoglycemia.

Hypersensitivity Reactions: Serious hypersensitivity reactions, including anaphylaxis, angioedema, and urticaria, have been reported with Victoza. Patients should be advised to discontinue Victoza 6 mg/ml injection and seek medical attention if they experience symptoms of a hypersensitivity reaction.

Renal Function Decline: Renal function decline is sometimes associated with acute renal failure and worsening chronic renal failure in patients treated with Victoza. Renal function should be monitored in patients with renal impairment.

Gallbladder Disease: Gallbladder disease, including cholelithiasis, is caused by Victoza. Patients should be monitored for signs and symptoms of gallbladder disease.

Cardiac Health: Monitor patients, particularly those with a history of cardiovascular disease, for any changes in heart rate or other cardiac symptoms during treatment.

Those who miss a Victoza 6 mg/ml injection dose should continue the once-daily dose as prescribed with the next planned dose. Do not take an extra dose or increase it to compensate if missed. During the first three days following your last Victoza dose, restart Victoza at 0.6 mg once daily to reduce the risk of gastrointestinal symptoms. If Victoza is reinstituted, the healthcare provider should titrate it at their discretion.

[Note: Always follow your healthcare provider’s instructions regarding Victoza dosing and missed doses to ensure optimal treatment outcomes].

An overdose of Victoza (Liraglutide) can lead to an increased risk of hypoglycemia (low blood sugar), nausea, vomiting, and gastrointestinal symptoms. In severe cases, it may result in dehydration, electrolyte imbalances, and acute kidney injury. Additionally, excessive doses of Victoza can exacerbate its side effects, such as gastrointestinal discomfort or pancreatitis.

[Note: If an overdose is suspected, immediate medical attention is necessary. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222].

It would help if you kept the Victoza (Liraglutide) pen refrigerated between 36°F and 46°F (2°C and 8°C) until you use it for the first time. Avoid placing the pen beside the refrigerator cooling element, as it might get too cold or freeze. When you use the pen for the first time, you can store it at room temperature between 59°F and 86°F (15°C to 30°C) or in the refrigerator. When not in use, keep the pen cap on.

Once your pen has been used, it lasts 30 days if kept at the right temperature. If the Victoza pen has been frozen previously, do not use it. Ensure it is protected from excessive heat and sunlight, and don’t leave it in the car.

Immediately remove the needle from the Victoza pen after each injection and discard it safely. When stored without the needle, contamination, infection, and leakage are reduced, and an accurate dose is achieved. To prevent contamination, always use a new needle for each injection.

[Note: Proper storage of Victoza is essential to maintain its stability and effectiveness. Follow these guidelines to ensure the safe and proper storage of your medication].

There are 255 drugs known to interact with Victoza (liraglutide), as well as 5 disease interactions and 2 alcohol/food interactions. There are 2 major drug interactions, 247 moderate interactions, and 6 minor interactions.

• Insulin
• Bexarotene (retinoids)
• Sulfonylureas (glipizide, glyburide)
• Dipeptidyl peptidase-4 (DPP-4) inhibitors (sitagliptin, saxagliptin)
• Thiazolidinediones (pioglitazone, rosiglitazone)
• Alpha-glucosidase inhibitors (acarbose, miglitol)
• SGLT-2 inhibitors (empagliflozin, dapagliflozin)
• Meglitinides (repaglinide, nateglinide)
• Beta-blockers (metoprolol, propranolol)
• ACE inhibitors (lisinopril, enalapril)
• ARBs (angiotensin II receptor blockers) (losartan, valsartan)
• Nonsteroidal anti-inflammatory drugs (NSAIDs) (ibuprofen, naproxen)
• Corticosteroids (prednisone, dexamethasone)
• Antipsychotic medications (olanzapine, risperidone)
• Antibiotics (gatifloxacin, ciprofloxacin, clarithromycin)
• Anticoagulants (warfarin, dabigatran)
• Oral contraceptives
• Antidepressants (sertraline, fluoxetine)
• Anticonvulsants (phenytoin, carbamazepine)
• Immunosuppressants (cyclosporine, tacrolimus)

What Are the Other Victoza Interactions?

Victoza (Liraglutide) can interact with several other substances, which can affect how well this medication works. Here are some notable interactions:

Victoza and Alcohol/Food Interactions

If you are considering using ethanol along with liraglutide, talk to your doctor first. Alcohol can affect blood sugar levels if you have diabetes. Depending on how much and how often you drink, hyperglycemia (high blood sugar) and hypoglycemia (low blood sugar) may occur. If you have diabetes, neuropathy (nerve damage), high triglycerides, or pancreatitis, you should avoid drinking alcohol. When your diabetes is under control, limited alcohol consumption does not affect blood glucose levels.

It is best to eat your normal meal plan and drink one drink daily (1 drink = 5 oz of wine, 12oz of beer, or 1.5oz of distilled spirits). Drinking alcohol on an empty stomach or after exercise may increase the risk of hypoglycemia. It would help to tell your doctor about all other medications you take, including vitamins and herbal supplements. If you plan to stop using any medication, consult your doctor first.

Victoza Disease Interactions

The following five diseases interact with Victoza (liraglutide):

• Thyroid carcinoma
• Pancreatitis
• Depression
• Cardiovascular disease
• Renal dysfunction

[Note: Discuss any concerns or questions about these interactions with your healthcare provider to ensure the safe and effective use of Victoza in your treatment regimen. Your healthcare provider can provide personalized guidance based on your medical history and individual health needs].

When you buy Victoza USA, you can also consider the alternatives of this medication. This includes:

• Other GLP-1 Receptor Agonists: There are several other GLP-1 receptor agonists available on the market, including:
  • Trulicity (dulaglutide)
  • Ozempic (semaglutide)
  • Adlyxin (lixisenatide)
• DPP-4 Inhibitors: Dipeptidyl peptidase-4 (DPP-4) inhibitors work by increasing insulin secretion and decreasing glucagon production. Some examples include:
  • Januvia (sitagliptin)
  • Onglyza (saxagliptin)
  • Tradjenta (linagliptin)
  • Nesina (alogliptin)
• SGLT-2 Inhibitors: Sodium-glucose cotransporter-2 (SGLT-2) inhibitors lower blood sugar by causing the kidneys to remove sugar through the urine. Examples include:
  • Invokana (canagliflozin)
  • Farxiga (dapagliflozin)
  • Jardiance (empagliflozin)
• Insulin: There are various types of insulin available, including short-acting, intermediate-acting, and long-acting insulins. Some examples include:
  • Humalog (insulin lispro)
  • Novolog (insulin aspart)
  • Lantus (insulin glargine)
  • Levemir (insulin detemir)
• Sulfonylureas: These medications stimulate the pancreas to release more insulin. Examples include:
  • Glucotrol (glipizide)
  • Diabeta (glyburide)
  • Amaryl (glimepiride)
• Thiazolidinediones: Thiazolidinediones help improve insulin sensitivity. Examples include:
  • Actos (pioglitazone)
  • Avandia (rosiglitazone)
• Meglitinides: These medications stimulate the pancreas to release more insulin, but they have a shorter action duration than sulfonylureas. Examples include:
  • Prandin (repaglinide)
  • Starlix (nateglinide)
• Combination Therapies: There are also combination medications available that combine different classes of anti-diabetic drugs into a single pill, such as:
  • Xigduo XR (dapagliflozin and Victoza)
  • Janumet (sitagliptin and Victoza)
  • Synjardy (empagliflozin and Victoza)

[Note: It’s essential to discuss these options with your healthcare provider to determine the most suitable treatment based on your individual health needs and medical history].

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The content provided on the Polar Bear Meds website serves to increase knowledge about healthcare products and medical conditions and is strictly for informational purposes. It should not replace professional medical advice. We urge you to consult with a qualified healthcare professional prior to utilizing any prescription or over-the-counter medication. Our platform grants access to an extensive array of products, sourced internationally, including Canada. We collaborates with a licensed pharmacy partner in Canada and trusted dispensing pharmacies globally. All affiliated fulfillment centers are accredited by the regulatory authorities of their respective countries.